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| Molecular remission after myeloablative allogeneic stem cell transplantation predicts a better relapse-free survival in patients with multiple myeloma |
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| Author(s): Corradini P, Cavo M, Lokhorst H, Martinelli G, Terragna C, Majolino I, Valagussa P, Boccadoro M, Samson D, Bacigalupo A, Russell N, Montefusco V, Voena C, Gahrton G |
| Source: BLOOD Volume: 102 Issue: 5 Pages: 1927-1929 Published: SEP 1 2003 |
| Times Cited: 63 References: 24 |
| Abstract: Patients in complete clinical remission after myeloablative allogeneic stem cell transplantation (allo-SCT) were enrolled in a longitudinal study to assess the predictive value of molecular monitoring. Using polymerase chain reaction (PCR) for immunoglobulin gene rearrangements it was possible to generate a clone-specific molecular marker in 48 of 70 patients. Of these 48 patients, 16 (33%) attained durable PCR-negativity after transplantation, whereas 13 (27%) remained persistently PCR-positive and 19 (40%) showed a mixed pattern. The cumulative risk of relapse at 5 years was 0% for PCR-negative patients, 33% for PCR-mixed patients, and 100% for PCR-positive patients. Within the group studied it was not possible to identify any clinical feature predictive of durable PCR-negativity. We believe that these findings could prompt the design of prospective studies to evaluate if the treatment of molecular disease can extend remission duration and survival. |
| Document Type: Article |
| Language: English |
| Reprint Address: Corradini, P (reprint author), Ist Nazl Studio & Cura Tumori, Hematol Bone Marrow Transplantat Unit, Via Venezian 1, I-20133 Milan, Italy |
Addresses:
1. Univ Milan, Ist Nazl Tumori, Hematol Bone Marrow Transplantat Unit, Milan, Italy
2. Univ Bologna, Ist Seragnoli, Dept Hematol, Bologna, Italy
3. Osped S Camillo Roma, Dept Hematol, Rome, Italy
4. Univ Turin, Dept Hematol, Turin, Italy
5. Osped San Martino Genova, Dept Hematol, Genoa, Italy
6. Univ Med Ctr, Dept Hematol, Utrecht, Netherlands
7. Hammersmith Hosp, Imperial Coll Sch Med, Dept Hematol, London, England
8. City Hosp Nottingham, Dept Hematol, Nottingham, England
9. Huddinge Univ Hosp, Dept Hematol, S-14186 Huddinge, Sweden |
| Publisher: AMER SOC HEMATOLOGY, 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA |
| Subject Category: Hematology |
| IDS Number: 714ZH |
| ISSN: 0006-4971 |
| DOI: 10.1182/blood-2003-01-0189 |
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