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| Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury |
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| Author(s): Agaisse H, Petersen UM, Boutros M, Mathey-Prevot B, Perrimon N |
| Source: DEVELOPMENTAL CELL Volume: 5 Issue: 3 Pages: 441-450 Published: SEP 2003 |
| Times Cited: 98 References: 41 |
| Abstract: To characterize the features of JAK/STAT signaling in Drosophila immune response, we have identified totA as a gene that is regulated by the JAK/STAT pathway in response to septic injury. We show that septic injury triggers the hemocyte-specific expression of upd3, a gene encoding a novel Upd-like cytokine that is necessary for the JAK/STAT-dependent activation of totA in the Drosophila counterpart of the mammalian liver, the fat body. In addition, we demonstrate that totA activation also requires the NF-KB-like Relish pathway, indicating that fat body cells integrate the activity of NF-KB and JAK/STAT signaling pathways upon immune response. This study reveals that, in addition to the pattern recognition receptor-mediated NF-KB-dependent immune response, Drosophila undergoes a complex systemic response that is mediated by the production of cytokines in blood cells, a process that is similar to the acute phase response in mammals. |
| Document Type: Article |
| Language: English |
| Reprint Address: Agaisse, H (reprint author), Harvard Univ, Sch Med, Dept Genet, 200 Longwood Ave, Boston, MA 02115 USA |
Addresses:
1. Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA
2. Howard Hughes Med Inst, Boston, MA 02115 USA
3. Dana Farber Canc Inst, Div Pediat Oncol & Hematol, Boston, MA 02115 USA |
| Publisher: CELL PRESS, 1100 MASSACHUSETTS AVE, CAMBRIDGE, MA 02138 USA |
| Subject Category: Cell Biology; Developmental Biology |
| IDS Number: 721GX |
| ISSN: 1534-5807 |
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