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| Androgen treatment of male hypogonadism in older males |
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| Author(s): Morley JE, Perry HM |
| Source: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY Volume: 85 Issue: 2-5 Pages: 367-373 Published: JUN 2003 |
| Times Cited: 28 References: 69 |
| Abstract: The treatment of primary and secondary hypogonadism with testosterone is well established. Recently, there has been increased awareness that low testosterone levels also occur in chronically ill persons and aging males. Because of sex hormone binding globulin changes, it is more appropriate to make the diagnosis using either free or bioavailable testosterone. A small number of controlled studies have suggested that testosterone replacement in older men improves libido, quality of erections, some aspects of cognition, muscle mass, muscles strength, and bone mineral density. It also decreases fat mass and leptin levels. A number of screening questionnaires for the andropause have been developed. Insufficient numbers of older men have been treated with testosterone to characterize the true incidence of side effects. There is a desperate need for well designed, large controlled trials to establish the value or otherwise of testosterone treatment in older males. Published by Elsevier Ltd. |
| Document Type: Proceedings Paper |
| Language: English |
| Reprint Address: Morley, JE (reprint author), St Louis Univ, Sch Med, VA Med Ctr, GRECC, 1402 S Grand Blvd,M238, St Louis, MO 63104 USA |
Addresses:
1. St Louis Univ, Sch Med, VA Med Ctr, GRECC, St Louis, MO 63104 USA
2. St Louis Univ, Sch Med, Div Geriatr Med, St Louis, MO 63104 USA |
| Publisher: PERGAMON-ELSEVIER SCIENCE LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND |
| Subject Category: Biochemistry & Molecular Biology; Endocrinology & Metabolism |
| IDS Number: 724NM |
| ISSN: 0960-0760 |
| DOI: 10.1016/S0960-0760(03)00203-6 |
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