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| (18)FDG-Positron emission tomography for the early prediction of response in advanced soft tissue sarcoma treated with imatinib mesylate (Glivec (R)) |
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| Author(s): Stroobants S, Goeminne J, Seegers M, Dimitrijevic S, Dupont P, Nuyts J, Martens M, van den Borne B, Cole P, Sciot R, Dumez H, Silberman S, Mortelmans L, van Oosterom A |
| Source: EUROPEAN JOURNAL OF CANCER Volume: 39 Issue: 14 Pages: 2012-2020 Published: SEP 2003 |
| Times Cited: 197 References: 27 |
| Abstract: Imatinib mesylate (Glivec(R), formerly ST1571) is the first effective systemic treatment for gastrointestinal stromal tumours (GISTs). Major changes in tumour volume, however, tend to occur late after the start of treatment. The aim of this study was to evaluate if [F-18]-fluorodeoxyglucose-positron emission tomography (FDG-PET) can be used for the early evaluation of response to imatinib mesylate treatment in soft-tissue sarcomas (STS). 21 patients (17 GIST, 4 other STS) underwent FDG-PET imaging prior to and 8 days after the start of treatment. PET response (European Organization for Research and Treatment (EORTC) guidelines) was observed in 13 GISTs (11 Complete Responders, 2 partial responders. Subsequent computerised tomography (CT) response Response Evaluation Criteria in Solid Tumours (RECIST) was observed in 10 of these patients after a median follow up of 8 weeks. Stable or progressive disease was observed on PET in 8 patients and none of them achieved a response on CT. PET response was also associated with a longer progression-free survival (PFS) (92% versus 12% at I year, P = 0.00107). We conclude that FDG-PET is an early and sensitive method to evaluate an early response to imatinib treatment. (C) 2003 Elsevier Ltd. All rights reserved. |
| Document Type: Article |
| Language: English |
| Reprint Address: Stroobants, S (reprint author), UZ Gasthuisberg, Dept Nucl Med, Herestr 49, B-3000 Louvain, Belgium |
Addresses:
1. UZ Gasthuisberg, Dept Nucl Med, B-3000 Louvain, Belgium
2. Univ Hosp Gasthuisberg, Dept Oncol, B-3000 Louvain, Belgium
3. Univ Hosp Gasthuisberg, Dept Pathol, B-3000 Louvain, Belgium
4. Novartis Pharma AG, Novartis Oncol, Basel, Switzerland
5. Novartis Pharmaceut, E Hanover, NJ USA |
| Publisher: PERGAMON-ELSEVIER SCIENCE LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND |
| Subject Category: Oncology |
| IDS Number: 724WV |
| ISSN: 0959-8049 |
| DOI: 10.1016/S0959-8049(03)00073-X |
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