| | |  | | | | Record from Web of Science® | | | | | | |
| Cross-priming of CD8(+) T cells stimulated by virus-induced type I interferon |
|
|
| Author(s): Le Bon A, Etchart N, Rossmann C, Ashton M, Hou S, Gewert D, Borrow P, Tough DF |
| Source: NATURE IMMUNOLOGY Volume: 4 Issue: 10 Pages: 1009-1015 Published: OCT 2003 |
| Times Cited: 255 References: 50 |
| Abstract: CD8(+) T cell responses can be generated against antigens that are not expressed directly within antigen-presenting cells (APCs), through a process known as cross-priming. To initiate cross-priming, APCs must both capture extracellular antigen and receive specific activation signals. We have investigated the nature of APC activation signals associated with virus infection that stimulate cross-priming. We show that infection with lymphocytic choriomeningitis virus induces cross-priming by a mechanism dependent on type I interferon (IFN-alpha/beta). Activation of cross-priming by IFN-alpha/beta was independent of CD4(+) T cell help or interaction of CD40 and CD40 ligand, and involved direct stimulation of dendritic cells. These data identify expression of IFN-alpha/beta as a mechanism for the induction of cross-priming during virus infections. |
| Document Type: Article |
| Language: English |
| Reprint Address: Tough, DF (reprint author), Edward Jenner Inst Vaccine Res, Newbury RG20 7NN, Berks England |
Addresses:
1. Edward Jenner Inst Vaccine Res, Newbury RG20 7NN, Berks England
2. Acambis, Cambridge CB1 9PT, England
3. BioLauncher, Cambridge CB4 3PE, England |
| Publisher: NATURE PUBLISHING GROUP, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 USA |
| Subject Category: Immunology |
| IDS Number: 726GG |
| ISSN: 1529-2908 |
| DOI: 10.1038/ni978 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |