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| Perspective: Evolution and detection of genetic robustness |
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| Author(s): de Visser JAGM, Hermisson J, Wagner GP, Meyers LA, Bagheri HC, Blanchard JL, Chao L, Cheverud JM, Elena SF, Fontana W, Gibson G, Hansen TF, Krakauer D, Lewontin RC, Ofria C, Rice SH, von Dassow G, Wagner A, Whitlock MC |
| Source: EVOLUTION Volume: 57 Issue: 9 Pages: 1959-1972 Published: SEP 2003 |
| Times Cited: 147 References: 93 |
| Abstract: Robustness is the invariance of phenotypes in the face of perturbation. The robustness of phenotypes appears at various levels of biological organization, including gene expression, protein folding, metabolic flux, physiological homeostasis, development, and even organismal fitness. The mechanisms underlying robustness are diverse, ranging from thermodynamic stability at the RNA and protein level to behavior at the organismal level. Phenotypes can be robust either against heritable perturbations (e.g., mutations) or nonheritable perturbations (e.g., the weather). Here we primarily focus on the first kind of robustness-genetic robustness-and survey three growing avenues of research: (1) measuring genetic robustness in nature and in the laboratory; (2) understanding the evolution of genetic robustness; and (3) exploring the implications of genetic robustness for future evolution. |
| Document Type: Article |
| Language: English |
| Reprint Address: de Visser, JAGM (reprint author), Univ Wageningen & Res Ctr, Dept Genet, Arboretumlaan 4, NL-6703 BD Wageningen, Netherlands |
Addresses:
1. Univ Wageningen & Res Ctr, Dept Genet, NL-6703 BD Wageningen, Netherlands
2. Univ Munich, Dept Biol 2, D-80333 Munich, Germany
3. Yale Univ, Dept Ecol & Evolutionary Biol, New Haven, CT 06520 USA
4. Univ Texas, Austin, TX 78712 USA
5. Santa Fe Inst, Santa Fe, NM 87501 USA
6. Natl Ctr Genome Resources, Santa Fe, NM 87501 USA
7. Univ Calif San Diego, La Jolla, CA 92093 USA
8. Washington Univ, Dept Anat & Neurobiol, St Louis, MO 63130 USA
9. CSIC, Inst Biol Mol & Celular Plantas, Valencia 46022, Spain
10. N Carolina State Univ, Dept Genet, Raleigh, NC 27695 USA
11. Florida State Univ, Dept Biol Sci, Tallahassee, FL 32306 USA
12. Harvard Univ, Museum Comparat Zool, Cambridge, MA 02138 USA
13. Harvard Univ, Dept Populat Biol, Cambridge, MA 02138 USA
14. Michigan State Univ, Ctr Microbial Ecol, E Lansing, MI 48324 USA
15. Univ Washington, Friday Harbor Labs, Friday Harbor, WA 98250 USA
16. Univ New Mexico, Dept Biol, Albuquerque, NM 87131 USA
17. Univ British Columbia, Dept Zool, Vancouver, BC V6T 1Z4 Canada |
| Publisher: SOC STUDY EVOLUTION, 810 E 10TH STREET, LAWRENCE, KS 66044 USA |
| Subject Category: Ecology; Evolutionary Biology; Genetics & Heredity |
| IDS Number: 727TB |
| ISSN: 0014-3820 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |