| | |  | | | | Record from Web of Science® | | | | | | |
| Talin binding to integrin beta tails: A final common step in integrin activation |
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| Author(s): Tadokoro S, Shattil SJ, Eto K, Tai V, Liddington RC, de Pereda JM, Ginsberg MH, Calderwood DA |
| Source: SCIENCE Volume: 302 Issue: 5642 Pages: 103-106 Published: OCT 3 2003 |
| Times Cited: 353 References: 23 |
| Abstract: Control of integrin affinity for ligands (integrin activation) is essential for normal cell adhesion, migration, and assembly of an extracellular matrix. Integrin activation is usually mediated through the integrin beta subunit cytoplasmic tail and can be regulated by many different biochemical signaling pathways. We report that specific binding of the cytoskeletal protein talin to integrin beta subunit cytoplasmic tails leads to the conformational rearrangements of integrin extracellular domains that increase their affinity. Thus, regulated binding of talin to integrin beta tails is a final common element of cellular signaling cascades that control integrin activation. |
| Document Type: Article |
| Language: English |
| Reprint Address: Ginsberg, MH (reprint author), Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA |
Addresses:
1. Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA
2. Burnham Inst, Program Cell Adhes, La Jolla, CA 92037 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 727UD |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |