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| Peri-engraftment clinical abnormalities following allogeneic hematopoietic cell transplantation: a retrospective review of 216 patients |
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| Author(s): Choi SJ, Lee KH, Lee JH, Lee JH, Kim S, Seol M, Lee YS, Kim WK, Park CJ, Chi HS, Lee JS |
| Source: BONE MARROW TRANSPLANTATION Volume: 32 Issue: 8 Pages: 809-813 Published: OCT 2003 |
| Times Cited: 4 References: 11 |
| Abstract: To evaluate the significance of clinical abnormalities occurring during the peri-engraftment period following allogeneic hematopoietic cell transplantation (HCT), we retrospectively analyzed the data of 216 allogeneic HCT recipients. The most frequently observed peri-engraftment clinical abnormality (PECA) was noninfectious fever in 58 patients, followed by hepatic dysfunction in 39, weight gain in 22, and renal insufficiency in 11. Frequently identified predictive factors for a higher incidence of each PECA were HCT from an unrelated or mismatched donor, GVHD prophylaxis with cyclosporine alone, and rapid engraftment. Considering that donor type and GVHD prophylaxis are closely related to GVHD, these observations suggest that the development of PECAs might be associated with a graft-versus-host reaction. This hypothesis was supported by the fact that the patient group with each PECA showed a higher incidence of grades 3-4 acute or chronic extensive GVHD, with varying degrees of statistical significance. Although our data should be interpreted cautiously in view of their retrospective nature, some of the PECAs occurring after allogeneic HCT may be atypical manifestations of GVHD and may be associated with severe forms of acute or chronic GVHD. |
| Document Type: Article |
| Language: English |
| Reprint Address: Choi, SJ (reprint author), Asan Med Ctr, Dept Internal Med, Div Hematol & Oncol, 388-1 Poongnap Dong, Seoul 138736, South Korea |
Addresses:
1. Asan Med Ctr, Dept Internal Med, Div Hematol & Oncol, Seoul 138736, South Korea
2. Univ Ulsan, Coll Med, Asan Med Ctr, Dept Lab Med, Seoul, South Korea |
| Publisher: NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND |
| Subject Category: Biophysics; Oncology; Hematology; Immunology; Transplantation |
| IDS Number: 729XB |
| ISSN: 0268-3369 |
| DOI: 10.1038/sj.bmt.1704224 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |