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| A gene expression atlas of the central nervous system based on bacterial artificial chromosomes |
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| Author(s): Gong SC, Zheng C, Doughty ML, Losos K, Didkovsky N, Schambra UB, Nowak NJ, Joyner A, Leblanc G, Hatten ME, Heintz N |
| Source: NATURE Volume: 425 Issue: 6961 Pages: 917-925 Published: OCT 30 2003 |
| Times Cited: 328 References: 46 |
| Abstract: The mammalian central nervous system (CNS) contains a remarkable array of neural cells, each with a complex pattern of connections that together generate perceptions and higher brain functions. Here we describe a large-scale screen to create an atlas of CNS gene expression at the cellular level, and to provide a library of verified bacterial artificial chromosome (BAC) vectors and transgenic mouse lines that offer experimental access to CNS regions, cell classes and pathways. We illustrate the use of this atlas to derive novel insights into gene function in neural cells, and into principal steps of CNS development. The atlas, library of BAC vectors and BAC transgenic mice generated in this screen provide a rich resource that allows a broad array of investigations not previously available to the neuroscience community. |
| Document Type: Article |
| Language: English |
| Reprint Address: Heintz, N (reprint author), Rockefeller Univ, Howard Hughes Med Inst, Mol Biol Lab, 1230 York Ave,Box 260, New York, NY 10021 USA |
Addresses:
1. Rockefeller Univ, Howard Hughes Med Inst, Mol Biol Lab, New York, NY 10021 USA
2. Rockefeller Univ, Howard Hughes Med Inst, GENSAT Project, New York, NY 10021 USA
3. Rockefeller Univ, Howard Hughes Med Inst, Dev Neurobiol Lab, New York, NY 10021 USA
4. E Tennessee State Univ, Dept Anat & Cell Biol, Johnson City, TN 37614 USA
5. Roswell Pk Canc Inst, Buffalo, NY 14263 USA
6. NYU, Sch Med, Dept Cell Biol, Skirball Inst Biomol Med,Dev Genet Program, New York, NY 10016 USA
7. Howard Hughes Med Inst, New York, NY 10016 USA
8. Natl Inst Neurol Disorders & Stroke, NIH, Bethesda, MD 20892 USA |
| Publisher: NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 737KY |
| ISSN: 0028-0836 |
| DOI: 10.1038/nature02033 |
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