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| Mutations of the BRAF gene in benign and malignant melanocytic lesions |
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| Author(s): Yazdi AS, Palmedo G, Flaig MJ, Puchta U, Reckwerth A, Rutten A, Mentzel T, Hugel H, Hantschke M, Schmid-Wendtner MH, Kutzner H, Sander CA |
| Source: JOURNAL OF INVESTIGATIVE DERMATOLOGY Volume: 121 Issue: 5 Pages: 1160-1162 Published: NOV 2003 |
| Times Cited: 95 References: 15 |
| Abstract: A single-point mutation in exon 15 of the BRAF gene has recently been reported in a high percentage in cultured melanoma cells and in 6 of 9 primary melanomas examined. To evaluate the impact of the T1796A BRAF mutation, we screened primary melanomas, various types of nevi and lesions where a melanoma developed in an underlying nevus. We could detect the mutation in 28 of 97 (29%) melanomas and in 39 of 187 (21%) nevi, including blue nevi (0/20) and Spitz nevi (0/69), which did not carry the mutation. In melanomas with an underlying nevus, either the mutation was present in both the laser-microdissected nevus cells and the laser-microdissected melanoma cells (3/14) or both lesions were negative for the BRAF mutation except one case. In conclusion, mutations in exon 15 of the BRAF gene are nonspecific for progression of a nevus to a melanoma. Other so far unknown cofactors seem to be of importance. |
| Document Type: Article |
| Language: English |
| Reprint Address: Sander, CA (reprint author), , Frauenlobstr 9-11, D-80337 Munich, Germany |
Addresses:
1. Univ Munich, Dept Dermatol, D-8000 Munich, Germany
2. Dermatohistopathol Gemeinschaftspraxis, Friedrichshafen, Germany |
| Publisher: BLACKWELL PUBLISHING INC, 350 MAIN ST, MALDEN, MA 02148 USA |
| Subject Category: Dermatology |
| IDS Number: 739VM |
| ISSN: 0022-202X |
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