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| The IL-12 family of heterodimeric cytokines: New players in the regulation of T cell responses |
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| Author(s): Trinchieri G, Pflanz S, Kastelein RA |
| Source: IMMUNITY Volume: 19 Issue: 5 Pages: 641-644 Published: NOV 2003 |
| Times Cited: 286 References: 18 |
| Abstract: Originally the only known heterodimeric cytokine, IL-12 is now part of a family of five cytokines and shares important functions in the regulation of both innate and adaptive immunity with two of them, IL-23 and IL-27. Although initially these three cytokines were considered to have largely overlapping immunological functions, more recent studies, including two articles in this issue of Immunity (Hamano et al., 2003; Villarino et al., 2003), indicate that they mediate complex and well-differentiated functions. |
| Document Type: Review |
| Language: English |
| Reprint Address: Trinchieri, G (reprint author), Schering Plough Corp, Res Inst, Lab Immunol Res, F-69571 Dardilly, France |
Addresses:
1. Schering Plough Corp, Res Inst, Lab Immunol Res, F-69571 Dardilly, France
2. DNAX Res Inst Mol & Cellular Biol Inc, Dept Discovery Biol, Palo Alto, CA 94304 USA |
| Publisher: CELL PRESS, 1100 MASSACHUSETTS AVE, CAMBRIDGE, MA 02138 USA |
| Subject Category: Immunology |
| IDS Number: 745CY |
| ISSN: 1074-7613 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |