| | |  | | | | Record from Web of Science® | | | | | | |
| Epithelial-mesenchymal transitions in development and pathologies |
|
|
| Author(s): Thiery JP |
| Source: CURRENT OPINION IN CELL BIOLOGY Volume: 15 Issue: 6 Pages: 740-746 Published: DEC 2003 |
| Times Cited: 421 References: 42 |
| Abstract: The epithelial-mesenchymal transition (EMT) is a fundamental process governing morphogenesis in multicellular organisms. This process is also reactivated in a variety of diseases including fibrosis and in the progression of carcinoma. The molecular mechanisms of EMT were primarily studied in epithelial cell lines, leading to the discovery of transduction pathways involved in the loss of epithelial cell polarity and the acquisition of a variety of mesenchymal phenotypic traits. Similar mechanisms have also been uncovered in vivo in different species, showing that EMT is controlled by remarkably well-conserved mechanisms. Current studies further emphasise the critical importance of EMT and provide a better molecular and functional definition of mesenchymal cells and how they emerged >500 million years ago as a key event in evolution. |
| Document Type: Article |
| Language: English |
| Reprint Address: Thiery, JP (reprint author), Inst Curie, CNRS, UMR 144, 26 Rue Ulm, F-75248 Paris 05, France |
Addresses:
1. Inst Curie, CNRS, UMR 144, F-75248 Paris 05, France |
| Publisher: CURRENT BIOLOGY LTD, 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND |
| Subject Category: Cell Biology |
| IDS Number: 751VF |
| ISSN: 0955-0674 |
| DOI: 10.1016/j.ceb.2003.10.006 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |