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| Critical roles for transcription factor GATA-3 in thymocyte development |
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| Author(s): Pai SY, Truitt ML, Ting CN, Leiden JM, Glimcher LH, Ho IC |
| Source: IMMUNITY Volume: 19 Issue: 6 Pages: 863-875 Published: DEC 2003 |
| Times Cited: 96 References: 43 |
| Abstract: The transcription factor GATA-3 is expressed at every stage of thymic development, but its role in thymocyte differentiation is unknown. The fact that RAG chimeric animals lacking GATA-3 cannot generate early thymocytes from common lymphoid progenitors has thus far precluded investigation of the function of GATA-3 in the thymus. To address this, we generated mice deficient in GATA-3 at early and late stages of thymic differentiation. Our studies revealed that GATA-3 is involved in beta selection and is indispensable for single-positive CD4 thymocyte development. Thus, our data demonstrate that the coordinated and regulated expression of GATA-3 at each stage of thymic development is critical for the generation of mature T cells. |
| Document Type: Article |
| Language: English |
| Reprint Address: Ho, IC (reprint author), Dana Farber Canc Inst, Dept Pediat Hematol & Oncol, Boston, MA 02115 USA |
Addresses:
1. Dana Farber Canc Inst, Dept Pediat Hematol & Oncol, Boston, MA 02115 USA
2. Childrens Hosp, Boston, MA 02115 USA
3. Harvard Univ, Sch Med, Boston, MA 02115 USA
4. Harvard Univ, Sch Publ Hlth, Ctr Prevent Cardiovasc Dis, Boston, MA 02115 USA
5. Harvard Univ, Sch Publ Hlth, Div Infect Dis & Immunol, Boston, MA 02115 USA
6. Brigham & Womens Hosp, Div Rheumatol Allergy & Immunol, Boston, MA 02115 USA |
| Publisher: CELL PRESS, 1100 MASSACHUSETTS AVE, CAMBRIDGE, MA 02138 USA |
| Subject Category: Immunology |
| IDS Number: 753KN |
| ISSN: 1074-7613 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |