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| Adiponectin and metabolic syndrome |
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| Author(s): Matsuzawa Y, Funahashi T, Kihara S, Shimomura I |
| Source: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY Volume: 24 Issue: 1 Pages: 29-33 Published: JAN 2004 |
| Times Cited: 345 References: 36 |
| Abstract: In this review article, the crucial roles of adipocytes in the development of so-called metabolic syndrome and vascular disease are reviewed, focusing on adipocyte-derived bioactive substances, adipocytokines. Recent progress in adipocyte biology shows that adipocytes are not merely energy-storing cells but that they secrete a variety of hormones cytokines, growth factors, and other bioactive substances. To search for novel adipocytokines by the large-scale random sequence analysis of expressed genes in adipocytes, we identified an adipose-specific collagen-like molecule, adiponectin. This novel adipocytokine has plural biofunctions, such as antidiabetic, antiatherosclerotic, and antiinflammatory functions. Adiponectin plasma levels decrease with the accumulation of visceral adipose tissue. In this review, we discuss the link of adiponectin to visceral adiposity, insulin resistance, and vascular diseases. |
| Document Type: Review |
| Language: English |
| Reprint Address: Matsuzawa, Y (reprint author), Osaka Univ, Grad Sch, Sumitomo Hosp, Kita Ku, 5-3-20 Nakanoshima, Osaka 5300005, Japan |
Addresses:
1. Osaka Univ, Grad Sch, Sumitomo Hosp, Dept Internal Med & Mol Sci, Osaka 5300005, Japan |
| Publisher: LIPPINCOTT WILLIAMS & WILKINS, 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA |
| Subject Category: Hematology; Peripheral Vascular Disease |
| IDS Number: 760BV |
| ISSN: 1079-5642 |
| DOI: 10.1161/01.ATV.0000099786.99623.EF |
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