| | |  | | | | Record from Web of Science® | | | | | | |
| The IKKNF-kappa B system: A treasure trove for drug development |
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| Author(s): Karin M, Yamamoto Y, Wang QM |
| Source: NATURE REVIEWS DRUG DISCOVERY Volume: 3 Issue: 1 Pages: 17-26 Published: JAN 2004 |
| Times Cited: 493 References: 92 |
| Abstract: Nuclear factor-kappaB (NF-kappaB)/Rel transcription factors have been suspected since their discovery to play a pivotal role in chronic and acute inflammatory diseases. It now seems that aberrant regulation of NF-kappaB could also underlie autoimmune diseases and different types of cancer. Recently, NF-kappaB and the signalling pathways that regulate its activity have become a focal point for intense drug discovery and development efforts. Given the large number of major ailments in which aberrant regulation of NF-kappaB has been observed or is suspected, such efforts seem well justified. This review will discuss recent progress in the development of drugs that inhibit NF-kappaB activation, and consider their potential applications in inflammatory and autoimmune diseases, as well as cancer. |
| Document Type: Review |
| Language: English |
| Reprint Address: Karin, M (reprint author), Univ Calif San Diego, Sch Med, Dept Pharmacol, Lab Gene Regulat & Signal Transduct, 9500 Gilman Dr, La Jolla, CA 92093 USA |
Addresses:
1. Univ Calif San Diego, Sch Med, Dept Pharmacol, Lab Gene Regulat & Signal Transduct, La Jolla, CA 92093 USA
2. Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USA |
| Publisher: NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND |
| Subject Category: Biotechnology & Applied Microbiology; Pharmacology & Pharmacy |
| IDS Number: 760FU |
| ISSN: 1474-1776 |
| DOI: 10.1038/nrd1279 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |