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| Features of the metabolic syndrome after childhood craniopharyngioma |
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| Author(s): Srinivasan S, Ogle GD, Garnett SP, Briody JN, Lee JW, Cowell CT |
| Source: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM Volume: 89 Issue: 1 Pages: 81-86 Published: JAN 2004 |
| Times Cited: 39 References: 30 |
| Abstract: Obesity and multiple pituitary hormone deficiency are common complications after surgery for childhood craniopharyngioma. We hypothesized that post craniopharyngioma surgery, children are at high risk for the metabolic syndrome, including insulin resistance due to excess weight gain and GH deficiency. This study characterized body composition (anthropometry and dual energy x-ray absorptiometry) and metabolic outcomes in 15 children (10 males and 5 females; age, 12.2 yr; range, 7.2-18.5 yr) after surgical removal of craniopharyngioma. In 9 subjects, outcomes were compared with those of healthy age-, sex-, body mass index-, and pubertal stage-matched controls. Insulin sensitivity was measured by 40-min iv glucose tolerance test. Seventy-three percent of subjects were overweight or obese. Sixty-six percent had normal growth velocity without GH treatment. Subjects had increased abdominal adiposity (P = 0.008) compared with controls. However, there was no significant difference in total body fat. Subjects had higher fasting triglycerides (P = 0.02) and lower high density lipoprotein cholesterol to total cholesterol ratio (P = 0.015). Insulin sensitivity was equally reduced for subjects and controls (P = 0.86). After craniopharyngioma removal, patients had more features of the metabolic syndrome compared with controls. This could be a result of hypothalamic damage causing obesity and GH deficiency. Further studies exploring predictors of the metabolic syndrome after craniopharyngioma surgery are required. |
| Document Type: Article |
| Language: English |
| Reprint Address: Srinivasan, S (reprint author), Childrens Hosp Westmead, Inst Endocrinol & Diabet, Locked Bag 4001, Westmead, NSW 2145 Australia |
Addresses:
1. Childrens Hosp Westmead, Inst Endocrinol & Diabet, Westmead, NSW 2145 Australia
2. Childrens Hosp Westmead, Dept Nucl Med, Westmead, NSW 2145 Australia |
| Publisher: ENDOCRINE SOC, 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA |
| Subject Category: Endocrinology & Metabolism |
| IDS Number: 761ZU |
| ISSN: 0021-972X |
| DOI: 10.1210/jc.2003-030442 |
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