| | |  | | | | Record from Web of Science® | | | | | | |
| The Omp85 family of proteins is essential for outer membrane biogenesis in mitochondria and bacteria |
|
|
| Author(s): Gentle I, Gabriel K, Beech P, Waller R, Lithgow T |
| Source: JOURNAL OF CELL BIOLOGY Volume: 164 Issue: 1 Pages: 19-24 Published: JAN 5 2004 |
| Times Cited: 119 References: 41 |
| Abstract: Integral proteins in the outer membrane of mitochondria control all aspects of organelle biogenesis, being required for protein import, mitochondrial fission, and, in metazoans, mitochondrial aspects of programmed cell death. How these integral proteins are assembled in the outer membrane had been unclear. In bacteria, Omp85 is an essential component of the protein insertion machinery, and we show that members of the Omp85 protein family are also found in eukaryotes ranging from plants to humans. In eukaryotes, Omp85 is present in the mitochondrial outer membrane. The gene encoding Omp85 is essential for cell viability in yeast, and conditional omp85 mutants have defects that arise from compromised insertion of integral proteins like voltage-dependent anion channel (VDAC) and components of the translocase in the outer membrane of mitochondria (TOM) complex into the mitochondrial outer membrane. |
| Document Type: Article |
| Language: English |
| Reprint Address: Lithgow, T (reprint author), Univ Melbourne, Russell Grimwade Sch Biochem & Mol Biol, Melbourne, Vic 3010 Australia |
Addresses:
1. Univ Melbourne, Russell Grimwade Sch Biochem & Mol Biol, Melbourne, Vic 3010 Australia
2. Deakin Univ, Ctr Cellular & Mol Biol, Burwood 3125, Australia |
| Publisher: ROCKEFELLER UNIV PRESS, 1114 FIRST AVE, 4TH FL, NEW YORK, NY 10021 USA |
| Subject Category: Cell Biology |
| IDS Number: 763GA |
| ISSN: 0021-9525 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |