| | |  | | | | Record from Web of Science® | | | | | | |
| Bmi1, stem cells, and senescence regulation |
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| Author(s): Park IK, Morrison SJ, Clarke MF |
| Source: JOURNAL OF CLINICAL INVESTIGATION Volume: 113 Issue: 2 Pages: 175-179 Published: JAN 2004 |
| Times Cited: 93 References: 58 |
| Abstract: Stem cells generate the differentiated cell types within many organs throughout the lifespan of an organism and are thus ultimately responsible for the longevity of multicellular organisms. Therefore, senescence of stem cells must be prevented. Bmi1 is required for the maintenance of adult stem cells in some tissues partly because it represses genes that induce cellular senescence and cell death. |
| Document Type: Article |
| Language: English |
| Reprint Address: Clarke, MF (reprint author), Univ Michigan, Sch Med, Dept Internal Med, 1500 E Med Ctr Dr, Ann Arbor, MI 48109 USA |
Addresses:
1. Univ Michigan, Sch Med, Dept Internal Med, Ann Arbor, MI 48109 USA
2. Univ Michigan, Sch Med, Dept Cellular & Dev Biol, Ann Arbor, MI 48109 USA
3. Univ Michigan, Sch Med, Howard Hughes Med Inst, Ann Arbor, MI 48109 USA |
| Publisher: AMER SOC CLINICAL INVESTIGATION INC, 35 RESEARCH DR, STE 300, ANN ARBOR, MI 48103 USA |
| Subject Category: Medicine, Research & Experimental |
| IDS Number: 764EZ |
| ISSN: 0021-9738 |
| DOI: 10.1172/JCI200420800 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |