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| Critical role of mast cells in inflammatory diseases and the effect of acute stress |
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| Author(s): Theoharides TC, Cochrane DE |
| Source: JOURNAL OF NEUROIMMUNOLOGY Volume: 146 Issue: 1-2 Pages: 1-12 Published: JAN 2004 |
| Times Cited: 122 References: 241 |
| Abstract: Mast cells are not only necessary for allergic reactions, but recent findings indicate that they are also involved in a variety of neuroinflammatory diseases, especially those worsened by stress. In these cases, mast cells appear to be activated through their Fc receptors by immunoglobulins other than IgE, as well as by anaphylatoxins, neuropeptides and cytokines to secrete mediators selectively without overt degranulation. These facts can help us better understand a variety of sterile inflammatory conditions, such as multiple sclerosis (MS), migraines, inflammatory arthritis, atopic dermatitis, coronary inflammation, interstitial cystitis and irritable bowel syndrome, in which mast cells are activated without allergic degranulation. (C) 2003 Elsevier B.V. All rights reserved. |
| Document Type: Review |
| Language: English |
| Reprint Address: Theoharides, TC (reprint author), Tufts Univ, Sch Med, Dept Pharmacol & Expt Therapeut, 136 Harrison Ave, Boston, MA 02111 USA |
Addresses:
1. Tufts Univ, Sch Med, Dept Pharmacol & Expt Therapeut, Boston, MA 02111 USA
2. Tufts Univ, New England Med Ctr, Dept Biochem, Boston, MA 02111 USA
3. Tufts Univ, New England Med Ctr, Dept Internal Med, Boston, MA 02111 USA
4. Tufts Univ, Dept Biol, Medford, MA 02155 USA |
| Publisher: ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS |
| Subject Category: Immunology; Neurosciences |
| IDS Number: 767YC |
| ISSN: 0165-5728 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |