| | |  | | | | Record from Web of Science® | | | | | | |
| Timeline - The history of cancer epigenetics |
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| Author(s): Feinberg AP, Tycko B |
| Source: NATURE REVIEWS CANCER Volume: 4 Issue: 2 Pages: 143-153 Published: FEB 2004 |
| Times Cited: 487 References: 179 |
| Abstract: Since its discovery in 1983, the epigenetics of human cancer has been in the shadows of human cancer genetics. But this area has become increasingly visible with a growing understanding of specific epigenetic mechanisms and their role in cancer, including hypomethylation, hypermethylation, loss of imprinting and chromatin modification. This timeline traces the field from its conception to the present day. It also addresses the genetic basis of epigenetic changes - an emerging area that promises to unite cancer genetics and epigenetics, and might serve as a model for understanding the epigenetic basis of human disease more generally. |
| Document Type: Editorial Material |
| Language: English |
| Reprint Address: Feinberg, AP (reprint author), Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA |
Addresses:
1. Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA
2. Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21205 USA
3. Johns Hopkins Univ, Sch Med, Dept Mol Biol & Genet, Baltimore, MD 21205 USA
4. Columbia Univ Coll Phys & Surg, Inst Canc Genet, New York, NY 10032 USA
5. Columbia Univ Coll Phys & Surg, Dept Pathol, New York, NY 10032 USA |
| Publisher: NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND |
| Subject Category: Oncology |
| IDS Number: 768ZF |
| ISSN: 1474-175X |
| DOI: 10.1038/nrc1279 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |