| | |  | | | | Record from Web of Science® | | | | | | |
| ErbB receptors: Directing key signaling networks throughout life |
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| Author(s): Holbro T, Hynes NE |
| Source: ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY Volume: 44 Pages: 195-217 Published: 2004 |
| Times Cited: 174 References: 146 |
| Abstract: The epidermal growth factor (EGF)-related peptides bind the ErbB receptors, inducing the formation of different homo- and heterodimers. Receptor dimerization promotes activation of the intrinsic kinase, leading to phosphorylation of specific tyrosines located in the ErbB's cytoplasmic region. These phosphorylated residues serve as docking sites for a variety of signaling molecules whose recruitment stimulates intracellular signaling cascades, which ultimately control diverse genetic programs. Particular ligand-receptor complexes have essential roles in embryonic development as well as in the adult. Finally, ErbB receptors are being pursued as therapeutic targets because aberrant ErbB activity has been observed in many human cancers. In this review, we discuss these data in more detail, illustrating the importance of tightly regulated ErbB signaling throughout life. |
| Document Type: Review |
| Language: English |
| Reprint Address: Holbro, T (reprint author), Friedrich Miescher Inst Biomed Res, CH-4002 Basel, Switzerland |
Addresses:
1. Friedrich Miescher Inst Biomed Res, CH-4002 Basel, Switzerland |
| Publisher: ANNUAL REVIEWS, 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0139 USA |
| Subject Category: Pharmacology & Pharmacy; Toxicology |
| IDS Number: 780BJ |
| ISSN: 0362-1642 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |