In this paper, I will discuss recurrent patterns of synergy found in the literature and our laboratory between tumor suppressor genes. oncogenes, and signaling pathways that allows one to predict the signaling pathway in a given minor based upon the inactivation of a tumor suppressor gene. These patterns can be found in multiple different human neoplasms. Conversely, one call predict the inactivation of a tumor suppressor based upon the activation Status of a signaling pathway. This knowledge call be used by a clinician or pathologist with access to immunohistochemistry to make predictions based upon simple technologies and determine the signaling pathways involved in a patient's tumor. These strategies may be useful in the design of prevention and treatment strategies for cancer. Published by Elsevier Ltd.