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| Presynaptic NMDA receptors modulate glutamate release from primary sensory neurons in rat spinal cord dorsal horn |
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| Author(s): Bardoni R, Torsney C, Tong CK, Prandini M, MacDermott AB |
| Source: JOURNAL OF NEUROSCIENCE Volume: 24 Issue: 11 Pages: 2774-2781 Published: MAR 17 2004 |
| Times Cited: 47 References: 41 |
| Abstract: NMDA receptors have the potential to produce complex activity-dependent regulation of transmitter release when localized presynaptically. In the somatosensory system, NMDA receptors have been immunocytochemically detected on presynaptic terminals of primary afferents, and these have been proposed to drive release of substance P from central terminals of a subset of nociceptors in the spinal cord dorsal horn. Here we report that functional NMDA receptors are indeed present at or near the central terminals of primary afferent fibers. Furthermore, we show that activation of these presynaptic receptors results in an inhibition of glutamate release from the terminals. Some of these NMDA receptors may be expressed in the preterminal axon and regulate the extent to which action potentials invade the extensive central arborizations of primary sensory neurons. |
| Document Type: Article |
| Language: English |
| Reprint Address: Bardoni, R (reprint author), Univ Modena & Reggio Emilia, Dept Biomed Sci, Physiol Sect, Via Campi 287, I-41100 Modena, Italy |
Addresses:
1. Univ Modena & Reggio Emilia, Dept Biomed Sci, Physiol Sect, I-41100 Modena, Italy
2. Columbia Univ, Ctr Neurobiol & Behav, New York, NY 10032 USA
3. Columbia Univ, Dept Physiol & Cellular Biophys, New York, NY 10032 USA |
| Publisher: SOC NEUROSCIENCE, 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA |
| Subject Category: Neurosciences |
| IDS Number: 804EH |
| ISSN: 0270-6474 |
| DOI: 10.1523/JNEUROSCI.4637-03.2004 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |