| | |  | | | | Record from Web of Science® | | | | | | |
| Nuclear retinoid receptors and the transcription of retinoid-target genes |
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| Author(s): Bastien J, Rochette-Egly C |
| Source: GENE Volume: 328 Pages: 1-16 Published: MAR 17 2004 |
| Times Cited: 219 References: 144 |
| Abstract: The pleiotropic effects of retinoids are mediated by nuclear retinoid receptors (RARs and RXRs) which are ligand-activated transcription factors. In response to retinoid binding, RAR/RXR heterodimers undergo major conformational changes and orchestrate the transcription of specific gene networks, through binding to specific DNA response elements and recruiting cofactor complexes that act to modify local chromatin structure and/or engage the basal transcription machinery. Then the degradation of RARs and RXRs by the ubiquitin-proteasome controls the magnitude and the duration of the retinoid response. RARs and RXRs also integrate a variety of signaling pathways through phosphorylation events which cooperate with the ligand for the control of retinoid-target genes transcription. These different modes of regulation reveal unexpected levels of complexity in the dynamics of retinoid-dependent transcription. (C) 2004 Elsevier B.V. All rights reserved. |
| Document Type: Review |
| Language: English |
| Reprint Address: Rochette-Egly, C (reprint author), ULP, CNRS UMR 7104, INSERM, Inst Genet & Biol Mol & Cellulaire, 1 Rue Laurent Fries,BP 10142, F-67404 Illkirch Graffenstaden, France |
Addresses:
1. ULP, CNRS UMR 7104, INSERM, Inst Genet & Biol Mol & Cellulaire, F-67404 Illkirch Graffenstaden, France |
| Publisher: ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS |
| Subject Category: Genetics & Heredity |
| IDS Number: 807YS |
| ISSN: 0378-1119 |
| DOI: 10.1016/j.gene.2003.12.005 |
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