| | |  | | | | Record from Web of Science® | | | | | | |
| Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity |
|
|
| Author(s): Liu LD, Wong TP, Pozza MF, Lingenhoehl K, Wang YS, Sheng M, Auberson YP, Wang YT |
| Source: SCIENCE Volume: 304 Issue: 5673 Pages: 1021-1024 Published: MAY 14 2004 |
| Times Cited: 340 References: 36 |
| Abstract: Activation of N-methyl-D-aspartate subtype glutamate receptors (NMDARs) is required for long-term potentiation (LTP) and long-term depression (LTD) of excitatory synaptic transmission at hippocampal CA1 synapses, the proposed cellular substrates of learning and memory. However, little is known about how activation of NMDARs leads to these two opposing forms of synaptic plasticity. Using hippocampal slice preparations, we showed that selectively blocking NMDARs that contain the NR2B subunit abolishes the induction of LTD but not LTP. In contrast, preferential inhibition of NR2A-containing NMDARs prevents the induction of LTP without affecting LTD production. These results demonstrate that distinct NMDAR subunits are critical factors that determine the polarity of synaptic plasticity. |
| Document Type: Article |
| Language: English |
| Reprint Address: Wang, YT (reprint author), Univ British Columbia, Brain Res Ctr, 2211 Wesbrook Mall, Vancouver, BC V6T 2B5 Canada |
Addresses:
1. Univ British Columbia, Brain Res Ctr, Vancouver, BC V6T 2B5 Canada
2. Novartis Pharma AG, Novartis Inst Biomed Res, CH-4002 Basel, Switzerland
3. MIT, Picower Ctr Learning & Memory, RIKE MIT Neurosci Res Ctr, Howard Hughes Med Inst, Cambridge, MA 02139 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 820IV |
| ISSN: 0036-8075 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |