| | |  | | | | Record from Web of Science® | | | | | | |
| Ubiquitin ligases and the immuneresponse |
|
|
| Author(s): Liu YC |
| Source: ANNUAL REVIEW OF IMMUNOLOGY Volume: 22 Pages: 81-127 Published: 2004 |
| Times Cited: 111 References: 313 |
| Abstract: Ubiquitin (Ub)-protein conjugation represents a novel means of post-transcriptional modification in a proteolysis-dependent or -independent manner. E3 Ub ligases play a key role in governing the cascade of Ub transfer reactions by recognizing and catalyzing Ub conjugation to specific protein substrates. The E3s, which can be generally classified into HECT-type and RING-type families, are involved in the regulation of many aspects of the immune system, including the development, activation, and differentiation of lymphocytes, T cell-tolerance induction, antigen presentation, immune evasion, and virus budding. E3-promoted ubiquitination affects a wide array of biological processes, such as receptor downmodulation, signal transduction, protein processing or translocation, protein-protein interaction, and gene transcription, in addition to proteasome-mediated degradation. Deficiency or mutation of some of the E3s like Cbl, Cbl-b, or Itch, causes abnormal immune responses such as autoimmunity, malignancy, and inflammation. This review discusses our current understanding of E3 Ub ligases in both innate and adaptive immunity. Such knowledge may facilitate the development of novel therapeutic approaches for immunological diseases. |
| Document Type: Review |
| Language: English |
| Reprint Address: Liu, YC (reprint author), La Jolla Inst Allergy & Immunol, Div Cell Biol, San Diego, CA 92121 USA |
Addresses:
1. La Jolla Inst Allergy & Immunol, Div Cell Biol, San Diego, CA 92121 USA |
| Publisher: ANNUAL REVIEWS, 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0139 USA |
| Subject Category: Immunology |
| IDS Number: 823HP |
| ISSN: 0732-0582 |
| DOI: 10.1146/annurev.immunol.22.012703.104813 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |