| Drosophila: The genetics of innate immune recognition and response |
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| Author(s): Brennan CA, Anderson KV |
| Source: ANNUAL REVIEW OF IMMUNOLOGY Volume: 22 Pages: 457-483 Published: 2004 |
| Times Cited: 134 References: 157 |
| Abstract: Because of the evolutionary conservation of innate mechanisms of host defense, Drosophila has emerged as an ideal animal in which to study the genetic control of immune recognition and responses. The discovery that the Toll pathway is required for defense against fungal infection in Drosophila was pivotal in studies of both mammalian and Drosophila immunity. Subsequent genetic screens in Drosophila to isolate additional mutants unable to induce humoral responses to infection have identified and ordered the function of components of two signaling cascades, the Toll and lmd pathways, that activate responses to infection. Drosophila blood cells also contribute to host defense through phagocytosis and signaling, and may carry out a form of self-nonself recognition that is independent of microbial pattern recognition. Recent work suggests that Drosophila will be a useful model for dissecting virulence mechanisms of several medically important pathogens. |
| Document Type: Review |
| Language: English |
| Reprint Address: Brennan, CA (reprint author), Mem Sloan Kettering Canc Ctr, Sloan Kettering Inst, 1275 York Ave, New York, NY 10021 USA |
Addresses:
1. Mem Sloan Kettering Canc Ctr, Sloan Kettering Inst, New York, NY 10021 USA |
| Publisher: ANNUAL REVIEWS, 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0139 USA |
| Subject Category: Immunology |
| IDS Number: 823HP |
| ISSN: 0732-0582 |
| DOI: 10.1146/annurev.immunol.22.012703.104626 |