| | |  | | | | Record from Web of Science® | | | | | | |
| RAGs and regulation of autoantibodies |
|
|
| Author(s): Jankovic M, Casellas R, Yannoutsos N, Wardemann H, Nussenzweig MC |
| Source: ANNUAL REVIEW OF IMMUNOLOGY Volume: 22 Pages: 485-501 Published: 2004 |
| Times Cited: 30 References: 142 |
| Abstract: Autoreactive antibodies are etiologic agents in a number of autoimmune diseases. Like all other antibodies these antibodies are produced in developing B cells by V(D)J recombination in the bone marrow. Three mechanisms regulate autoreactive B cells: deletion, receptor editing, and anergy. Here we review the prevalence of autoantibodies in the initial antibody repertoire, their regulation by receptor editing, and the role of the recombinase proteins (RAG l and RAG2) in this process. |
| Document Type: Review |
| Language: English |
| Reprint Address: Jankovic, M (reprint author), Rockefeller Univ, Lab Mol Immunol, New York, NY 10021 USA |
Addresses:
1. Rockefeller Univ, Lab Mol Immunol, New York, NY 10021 USA
2. Rockefeller Univ, Howard Hughes Med Inst, New York, NY 10021 USA
3. CALTECH, Div Biol, Pasadena, CA 91125 USA |
| Publisher: ANNUAL REVIEWS, 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0139 USA |
| Subject Category: Immunology |
| IDS Number: 823HP |
| ISSN: 0732-0582 |
| DOI: 10.1146/annurev.immunol.22.012703.104707 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |