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| Genetic signatures of strong recent positive selection at the lactase gene |
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| Author(s): Bersaglieri T, Sabeti PC, Patterson N, Vanderploeg T, Schaffner SF, Drake JA, Rhodes M, Reich DE, Hirschhorn JN |
| Source: AMERICAN JOURNAL OF HUMAN GENETICS Volume: 74 Issue: 6 Pages: 1111-1120 Published: JUN 2004 |
| Times Cited: 191 References: 40 |
| Abstract: In most human populations, the ability to digest lactose contained in milk usually disappears in childhood, but in European-derived populations, lactase activity frequently persists into adulthood (Scrimshaw and Murray 1988). It has been suggested (Cavalli-Sforza 1973; Hollox et al. 2001; Enattah et al. 2002; Poulter et al. 2003) that a selective advantage based on additional nutrition from dairy explains these genetically determined population differences (Simoons 1970; Kretchmer 1971; Scrimshaw and Murray 1988; Enattah et al. 2002), but formal population-genetics-based evidence of selection has not yet been provided. To assess the population-genetics evidence for selection, we typed 101 single-nucleotide polymorphisms covering 3.2 Mb around the lactase gene. In northern European-derived populations, two alleles that are tightly associated with lactase persistence ( Enattah et al. 2002) uniquely mark a common (similar to77%) haplotype that extends largely undisrupted for >1 Mb. We provide two new lines of genetic evidence that this long, common haplotype arose rapidly due to recent selection: ( 1) by use of the traditional F-ST measure and a novel test based on p(excess), we demonstrate large frequency differences among populations for the persistence-associated markers and for flanking markers throughout the haplotype, and ( 2) we show that the haplotype is unusually long, given its high frequency-a hallmark of recent selection. We estimate that strong selection occurred within the past 5,000-10,000 years, consistent with an advantage to lactase persistence in the setting of dairy farming; the signals of selection we observe are among the strongest yet seen for any gene in the genome. |
| Document Type: Article |
| Language: English |
| Reprint Address: Hirschhorn, JN (reprint author), Childrens Hosp, Div Genet, Enders 561,300 Longwood Ave, Boston, MA 02115 USA |
Addresses:
1. Childrens Hosp, Div Genet, Boston, MA 02115 USA
2. Childrens Hosp, Div Endocrinol, Boston, MA 02115 USA
3. Harvard Univ, Sch Med, Dept Genet, Boston, MA USA
4. Whitehead MIT Ctr Genome Res, Program Med & Populat Genet, Cambridge, MA USA |
| Publisher: UNIV CHICAGO PRESS, 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA |
| Subject Category: Genetics & Heredity |
| IDS Number: 823ZB |
| ISSN: 0002-9297 |
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