| | |  | | | | Record from Web of Science® | | | | | | |
| The stalk region of dynamin drives the constriction of dynamin tubes |
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| Author(s): Chen YJ, Zhang PJ, Egelman EH, Hinshaw JE |
| Source: NATURE STRUCTURAL & MOLECULAR BIOLOGY Volume: 11 Issue: 6 Pages: 574-575 Published: JUN 2004 |
| Times Cited: 47 References: 12 |
| Abstract: The GTPase dynamin is essential for numerous vesiculation events including clathrin-mediated endocytosis. Upon GTP hydrolysis, dynamin constricts a lipid bilayer. Previously, a three-dimensional structure of mutant dynamin in the constricted state was determined by helical reconstruction methods. We solved the nonconstricted state by a single-particle approach and show that the stalk region of dynamin undergoes a large conformational change that drives tube constriction. |
| Document Type: Article |
| Language: English |
| Reprint Address: Egelman, EH (reprint author), Univ Virginia, Dept Biochem & Mol Genet, Charlottesville, VA USA |
Addresses:
1. Univ Virginia, Dept Biochem & Mol Genet, Charlottesville, VA USA
2. NIDDKD, Lab Cell Biochem & Biol, NIH, Bethesda, MD 20892 USA |
| Publisher: NATURE PUBLISHING GROUP, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 USA |
| Subject Category: Biochemistry & Molecular Biology; Biophysics; Cell Biology |
| IDS Number: 824DO |
| ISSN: 1545-9985 |
| DOI: 10.1038/nsmb762 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |