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| Meta-analysis of genome-wide studies of psoriasis susceptibility reveals linkage to chromosomes 6p21 and 4q28-q31 in caucasian and chinese hans population |
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| Author(s): Sagoo GS, Tazi-Ahnini R, Barker JWN, Elder JT, Nair RP, Samuelsson L, Traupe H, Trembath RC, Robinson DA, Iles MM |
| Source: JOURNAL OF INVESTIGATIVE DERMATOLOGY Volume: 122 Issue: 6 Pages: 1401-1405 Published: JUN 2004 |
| Times Cited: 37 References: 31 |
| Abstract: Ten genome-wide scans have been conducted over the past few years in the search for psoriasis susceptibility genes, but only one potential susceptibility region has been consistently replicated. A meta-analysis using the genome-search meta-analysis method was undertaken combining the results of six of these psoriasis genome-wide studies. The results of this analysis revealed linkage to the major histocompatibility complex on chromosome 6p21 that includes the PSORS1 locus. In addition, linkage was also recorded to a region on chromosome 4q28-q31 previously identified only in a Chinese Hans population. Both these regions were statistically significant even after correction for multiple testing. A possible reason for the erratic replication of findings could be the large effect of the PSORS1 locus (6p21) masking the effect of other loci involved in psoriasis. To overcome this problem, we suggest that future studies condition on the effect of the PSORS1 locus. |
| Document Type: Article |
| Language: English |
| Reprint Address: Sagoo, GS (reprint author), Univ Sheffield, Royal Hallamshire Hosp, Div Genom Med, Biomed Genet Project, Beech Hill Rd, Sheffield S10 2RX, S Yorkshire England |
Addresses:
1. Univ Sheffield, Div Genom Med, Biomed Genet Project, Sheffield, S Yorkshire England
2. St Thomas Hosp, St Johns Inst Dermatol, Dept Dermatol, London, England
3. Univ Michigan, Sch Med, Dept Dermatol, Ann Arbor, MI USA
4. Sahlgrenska Univ Hosp E, Dept Clin Genet, Gothenburg, Sweden
5. Univ Hosp Muenster, Dept Dermatol, Munster, Germany
6. Univ Leicester, Dept Genet, Div Med Genet, Leicester LE1 7RH, Leics England
7. Univ Leicester, Dept Cardiovasc Sci, Div Med Genet, Leicester, Leics England |
| Publisher: BLACKWELL PUBLISHING INC, 350 MAIN ST, MALDEN, MA 02148 USA |
| Subject Category: Dermatology |
| IDS Number: 824NO |
| ISSN: 0022-202X |
| DOI: 10.1111/j.0022-202X.2004.22607.x |
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