| | |  | | | | Record from Web of Science® | | | | | | |
| Biosynthesis of volatiles by the myxobacterium Myxococcus xanthus |
|
|
| Author(s): Dickschat JS, Wenzel SC, Bode HB, Muller R, Schulz S |
| Source: CHEMBIOCHEM Volume: 5 Issue: 6 Pages: 778-787 Published: JUN 7 2004 |
| Times Cited: 33 References: 35 |
| Abstract: The volatiles emitted from cell cultures of myxobacterium Myxococcus xanthus were collected by use of a closed-loop stripping apparatus (CLSA) and analyzed by GC-MS. Two new natural products, (S)-9-methyldecan-3-ol ((S)-1) and 9-methyldecan-3-one (2), were identified and synthesized, together with other aliphatic ketones and alcohols, and terpenes, Biosynthesis, of the two main components (S)-1 2 was examined in feeding experiments carried out with the wild-type strain DK1622 and two mutant strains JD300 and KD11017, which are impaired in the degradation pathway from leucine to isovaleryl-SCoA. Isovaleryl-SCoA is used as a starter, followed by chain elongation with two malonate units. Subsequent use of methyl malonate and decarboxylation leads to (S)-1 and 2. Furthermore, 3,3-dimethylacrylic acid (DMAA) can be used by the mutant strain to form isovaleryl- SCoA, which corroborates, recent data on the detection of a novel variety of the mevalonate pathway giving rise to isovaleryl-SCoA from HMGCoA. |
| Document Type: Article |
| Language: English |
| Reprint Address: Muller, R (reprint author), Gesell Biotechnol Forsch mbH, Mascheroder Weg 1, D-38124 Braunschweig, Germany |
Addresses:
1. Gesell Biotechnol Forsch mbH, D-38124 Braunschweig, Germany
2. Tech Univ Carolo Wilhelmina Braunschweig, Inst Organ Chem, D-38106 Braunschweig, Germany |
| Publisher: WILEY-V C H VERLAG GMBH, PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY |
| Subject Category: Biochemistry & Molecular Biology; Chemistry, Medicinal |
| IDS Number: 828KK |
| ISSN: 1439-4227 |
| DOI: 10.1002/cbic.200300813 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |