| | |  | | | | Record from Web of Science® | | | | | | |
| Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus |
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| Author(s): Hong YK, Foreman K, Shin JW, Hirakawa S, Curry CL, Sage DR, Libermann T, Dezube BJ, Fingeroth JD, Detmar M |
| Source: NATURE GENETICS Volume: 36 Issue: 7 Pages: 683-685 Published: JUL 2004 |
| Times Cited: 94 References: 15 |
| Abstract: Kaposi sarcoma is considered a neoplasm of lymphatic endothelium infected with Kaposi sarcoma-associated herpesvirus. It is characterized by the expression of lymphatic lineage-specific genes by Kaposi sarcoma tumor cells. Here we show that infection of differentiated blood vascular endothelial cells with Kaposi sarcoma-associated herpesvirus leads to their lymphatic reprogramming; induction of similar to70% of the main lymphatic lineage-specific genes, including PROX1, a master regulator of lymphatic development; and downregulation of blood vascular genes. |
| Document Type: Article |
| Language: English |
| Reprint Address: Detmar, M (reprint author), Massachusetts Gen Hosp, Cutaneous Biol Res Ctr, Bldg 149,13th St, Charlestown, MA 02129 USA |
Addresses:
1. Massachusetts Gen Hosp, Cutaneous Biol Res Ctr, Charlestown, MA 02129 USA
2. Harvard Univ, Sch Med, Charlestown, MA 02129 USA
3. Loyola Univ, Med Ctr, Maywood, IL 60153 USA
4. Beth Israel Deaconess Med Ctr, Dept Med, BIDMC Genom Ctr, Boston, MA 02215 USA
5. Beth Israel Deaconess Med Ctr, Div Infect Dis, Boston, MA 02215 USA
6. Harvard Univ, Sch Med, Boston, MA 02215 USA |
| Publisher: NATURE PUBLISHING GROUP, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 USA |
| Subject Category: Genetics & Heredity |
| IDS Number: 833QT |
| ISSN: 1061-4036 |
| DOI: 10.1038/ng1383 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |