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| Evidence for dynamically organized modularity in the yeast protein-protein interaction network |
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| Author(s): Han JDJ, Bertin N, Hao T, Goldberg DS, Berriz GF, Zhang LV, Dupuy D, Walhout AJM, Cusick ME, Roth FP, Vidal M |
| Source: NATURE Volume: 430 Issue: 6995 Pages: 88-93 Published: JUL 1 2004 |
| Times Cited: 384 References: 28 |
| Abstract: In apparently scale-free protein-protein interaction networks, or 'interactome' networks(1,2), most proteins interact with few partners, whereas a small but significant proportion of proteins, the 'hubs', interact with many partners. Both biological and nonbiological scale-free networks are particularly resistant to random node removal but are extremely sensitive to the targeted removal of hubs(1). A link between the potential scale-free topology of interactome networks and genetic robustness(3,4) seems to exist, because knockouts of yeast genes(5,6) encoding hubs are approximately threefold more likely to confer lethality than those of non-hubs(1). Here we investigate how hubs might contribute to robustness and other cellular properties for protein protein interactions dynamically regulated both in time and in space. We uncovered two types of hub: 'party' hubs, which interact with most of their partners simultaneously, and 'date' hubs, which bind their different partners at different times or locations. Both in silico studies of network connectivity and genetic interactions described in vivo support a model of organized modularity in which date hubs organize the proteome, connecting biological processes-or modules(7)-to each other, whereas party hubs function inside modules. |
| Document Type: Article |
| Language: English |
| Reprint Address: Vidal, M (reprint author), Harvard Univ, Sch Med, Dana Farber Canc Inst, Ctr Canc Syst Biol, 44 Binney St, Boston, MA 02115 USA |
Addresses:
1. Harvard Univ, Sch Med, Dana Farber Canc Inst, Ctr Canc Syst Biol, Boston, MA 02115 USA
2. Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA
3. Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA
4. Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA |
| Publisher: NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 833RP |
| ISSN: 0028-0836 |
| DOI: 10.1038/nature02555 |
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