| | |  | | | | Record from Web of Science® | | | | | | |
| Cell death mode switch from necrosis to apoptosis in brain |
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| Author(s): Ueda H, Fujita R |
| Source: BIOLOGICAL & PHARMACEUTICAL BULLETIN Volume: 27 Issue: 7 Pages: 950-955 Published: JUL 2004 |
| Times Cited: 15 References: 61 |
| Abstract: In brain ischemia, cell destructive necrosis occurs in the core, which in turn links to cell death expansion in the vicinity. Apoptosis, on the other hand, occurs in the surroundings of the core, called the penumbra, several days later. As cells showing apoptosis disappear by microglial phagocytosis in the brain, cell death induced by ischemic stress should eventually be terminated. Thus, the authors propose the hypothesis that the cell death mode switch in the event of brain ischemia is an in vivo self-protective mechanism. The authors attempt to overview the current understanding of the molecular mechanisms of necrosis and apoptosis in relation to the ATP hypothesis, and also introduce novel mechanisms for an in vitro cell death mode switch. |
| Document Type: Article |
| Language: English |
| Reprint Address: Ueda, H (reprint author), Nagasaki Univ, Grad Sch Biomed Sci, Div Mol Pharmacol & Neurosci, 1-14 Bunkyo Machi, Nagasaki 8528521, Japan |
Addresses:
1. Nagasaki Univ, Grad Sch Biomed Sci, Div Mol Pharmacol & Neurosci, Nagasaki 8528521, Japan |
| Publisher: PHARMACEUTICAL SOC JAPAN, 2-12-15-201 SHIBUYA, SHIBUYA-KU, TOKYO, 150, JAPAN |
| Subject Category: Pharmacology & Pharmacy |
| IDS Number: 834OS |
| ISSN: 0918-6158 |
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