| | |  | | | | Record from Web of Science® | | | | | | |
| Injection of recombinant human type VII collagen restores collagen function in dystrophic epidermolysis bullosa |
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| Author(s): Woodley DT, Keene DR, Atha T, Huang Y, Lipman K, Li W, Chen M |
| Source: NATURE MEDICINE Volume: 10 Issue: 7 Pages: 693-695 Published: JUL 2004 |
| Times Cited: 21 References: 15 |
| Abstract: Dystrophic epidermolysis bullosa (DEB) is a family of inherited mechano-bullous disorders that are caused by mutations in the type VII collagen gene and for which ex vivo gene therapy has been considered. To develop a simpler approach for treating DEB, we evaluated the feasibility of protein-based therapy by intradermally injecting human recombinant type VII collagen into mouse skin and a DEB human skin equivalent transplanted onto mice. The injected collagen localized to the basement membrane zone of both types of tissues, was organized into human anchoring fibril structures and reversed the features of DEB disease in the DEB skin equivalent. |
| Document Type: Article |
| Language: English |
| Reprint Address: Chen, M (reprint author), Univ So Calif, Div Dermatol, Dept Med, CRL 204,1303 Mission Rd, Los Angeles, CA 90033 USA |
Addresses:
1. Univ So Calif, Div Dermatol, Dept Med, Los Angeles, CA 90033 USA
2. Shriners Hosp Children, Portland, OR 97201 USA |
| Publisher: NATURE PUBLISHING GROUP, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 USA |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology; Medicine, Research & Experimental |
| IDS Number: 835DM |
| ISSN: 1078-8956 |
| DOI: 10.1038/nm1063 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |