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| Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia |
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| Author(s): Li KS, Guan Y, Wang J, Smith GJD, Xu KM, Duan L, Rahardjo AP, Puthavathana P, Buranathai C, Nguyen TD, Estoepangestie ATS, Chaisingh A, Auewarakul P, Long HT, Hanh NTH, Webby RJ, Poon LLM, Chen H, Shortridge KF, Yuen KY, Webster RG, Peiris JSM |
| Source: NATURE Volume: 430 Issue: 6996 Pages: 209-213 Published: JUL 8 2004 |
| Times Cited: 431 References: 26 |
| Abstract: A highly pathogenic avian influenza virus, H5N1, caused disease outbreaks in poultry in China and seven other east Asian countries between late 2003 and early 2004; the same virus was fatal to humans in Thailand and Vietnam(1). Here we demonstrate a series of genetic reassortment events traceable to the precursor of the H5N1 viruses that caused the initial human outbreak in Hong Kong in 1997 (refs 2-4) and subsequent avian outbreaks in 2001 and 2002 ( refs 5, 6). These events gave rise to a dominant H5N1 genotype (Z) in chickens and ducks that was responsible for the regional outbreak in 2003-04. Our findings indicate that domestic ducks in southern China had a central role in the generation and maintenance of this virus, and that wild birds may have contributed to the increasingly wide spread of the virus in Asia. Our results suggest that H5N1 viruses with pandemic potential have become endemic in the region and are not easily eradicable. These developments pose a threat to public and veterinary health in the region and potentially the world, and suggest that long-term control measures are required. |
| Document Type: Article |
| Language: English |
| Reprint Address: Guan, Y (reprint author), Shantou Univ, Coll Med, Joint Influenza Res Ctr, SUMC,HKU, Guangdong 515031, Peoples R China |
Addresses:
1. Shantou Univ, Coll Med, Joint Influenza Res Ctr, SUMC,HKU, Guangdong 515031, Peoples R China
2. Univ Hong Kong, Queen Mary Hosp, Dept Microbiol, Hong Kong, Hong Kong Peoples R China
3. Univ Airlangga, Fak Kedokteran Hewan, Surabaya 60115, Indonesia
4. Sriraj Hosp, Dept Microbiol, Bangkok 10700, Thailand
5. Natl Inst Anim Hlth, Dept Livestock Dev, Bangkok 10900, Thailand
6. Minist Agr & Rural Dev, Natl Inst Vet Res, Dept Virol, Hanoi, Vietnam
7. Natl Inst Hyg & Epidemiol, Dept Virol, Hanoi, Vietnam
8. St Jude Childrens Hosp, Dept Infect Dis, Div Virol, Memphis, TN 38105 USA |
| Publisher: NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 835GL |
| ISSN: 0028-0836 |
| DOI: 10.1038/nature02746 |
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