| | |  | | | | Record from Web of Science® | | | | | | |
| Protein interaction networks from yeast to human |
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| Author(s): Bork P, Jensen LJ, von Mering C, Ramani AK, Lee I, Marcotte EM |
| Source: CURRENT OPINION IN STRUCTURAL BIOLOGY Volume: 14 Issue: 3 Pages: 292-299 Published: JUN 2004 |
| Times Cited: 116 References: 75 |
| Abstract: Protein interaction networks summarize large amounts of protein-protein interaction data, both from individual, small-scale experiments and from automated high-throughput screens. The past year has seen a flood of new experimental data, especially on metazoans, as well as an increasing number of analyses designed to reveal aspects of network topology, modularity and evolution. As only minimal progress has been made in mapping the human proteome using high-throughput screens, the transfer of interaction information within and across species has become increasingly important. With more and more heterogeneous raw data becoming available, proper data integration and quality control have become essential for reliable protein network reconstruction, and will be especially important for reconstructing the human protein interaction network. |
| Document Type: Review |
| Language: English |
| Reprint Address: Bork, P (reprint author), European Mol Biol Lab, Struct & Computat Biol Programme, Meyerhofstr 1, Heidelberg, Germany |
Addresses:
1. European Mol Biol Lab, Struct & Computat Biol Programme, Heidelberg, Germany
2. Univ Texas, Inst Cell & Mol Biol, Ctr Syst & Synth Biol, Austin, TX 78712 USA |
| Publisher: CURRENT BIOLOGY LTD, 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: 836EM |
| ISSN: 0959-440X |
| DOI: 10.1016/j.sbi.2004.05.003 |
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