| | |  | | | | Record from Web of Science® | | | | | | |
| Spatial coordination of cytokinetic events by compartmentalization of the cell cortex |
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| Author(s): Dobbelaere J, Barral Y |
| Source: SCIENCE Volume: 305 Issue: 5682 Pages: 393-396 Published: JUL 16 2004 |
| Times Cited: 83 References: 26 |
| Abstract: During cytokinesis, furrow ingression and plasma membrane fission irreversibly separate daughter cells. How actomyosin ring assembly and contraction, vesicle fusion, and abscission are spatially coordinated was unknown. We found that during cytokinesis septin rings, located on both sides of the actomyosin ring, acted as barriers to compartmentalize the cortex around the cleavage site. Compartmentalization maintained diffusible cortical factors, such as the exocyst and the polarizome, to the site of cleavage. In turn, such factors were required for actomyosin ring function and membrane abscission. Thus, a specialized cortical compartment ensures the spatial coordination of cytokinetic events. |
| Document Type: Article |
| Language: English |
| Reprint Address: Barral, Y (reprint author), ETH Honggerberg, Swiss Fed Inst Technol, Inst Biochem, CH-8093 Zurich, Switzerland |
Addresses:
1. ETH Honggerberg, Swiss Fed Inst Technol, Inst Biochem, CH-8093 Zurich, Switzerland |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 837TE |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |