| | |  | | | | Record from Web of Science® | | | | | | |
| Interleukin-15: a new cytokine target for the treatment of inflammatory diseases |
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| Author(s): McInnes IB, Gracie JA |
| Source: CURRENT OPINION IN PHARMACOLOGY Volume: 4 Issue: 4 Pages: 392-397 Published: AUG 2004 |
| Times Cited: 78 References: 45 |
| Abstract: Interleukin (IL)-15 is a pleiotropic pro-inflammatory cytokine that is expressed in several inflammatory disorders, including rheumatoid arthritis, psoriasis and pulmonary inflammatory diseases. IL-15 promotes activation of T cells, neutrophils and macrophages, and is critical to dendritic cell function in several model systems. Recent emerging data suggest that IL-15 may serve as a useful therapeutic target across a range of disease states. Advances in the past year highlight the beneficial effect of IL-15 neutralisation in models of psoriasis and diabetes. Further evidence for IL-15 expression and effector function has emerged across a range of rheumatic disorders, including juvenile inflammatory arthritis, rheumatoid arthritis and Kawasaki disease. These data hold promise for therapeutic targeting in ongoing human studies and those in the near future. |
| Document Type: Review |
| Language: English |
| Reprint Address: McInnes, IB (reprint author), Glasgow Royal Infirm, Ctr Rheumat Dis, 10 Aleandra Parade, Glasgow G31 2ER, Lanark Scotland |
Addresses:
1. Glasgow Royal Infirm, Ctr Rheumat Dis, Glasgow G31 2ER, Lanark Scotland |
| Publisher: ELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND |
| Subject Category: Pharmacology & Pharmacy |
| IDS Number: 846LC |
| ISSN: 1471-4892 |
| DOI: 10.1016/j.coph.2004.04.003 |
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