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| CD133, a novel marker for human prostatic epithelial stem cells |
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| Author(s): Richardson GD, Robson CN, Lang SH, Neal DE, Maitland NJ, Collins AT |
| Source: JOURNAL OF CELL SCIENCE Volume: 117 Issue: 16 Pages: 3539-3545 Published: JUL 15 2004 |
| Times Cited: 197 References: 33 |
| Abstract: Stem cells are clonogenic cells with self-renewal and differentiation properties, which may represent a major target for genetic damage leading to prostate cancer and benign prostatic hyperplasia. Stem cells remain poorly characterised because of the absence of specific molecular markers that permit us to distinguish them from their progeny, the transit amplifying cells, which have a more restricted proliferative potential. Human CD133 antigen, also known as AC133, was recently identified as a haematopoietic stem cell marker. Here we show that a small population (approximately 1 %) of human prostate basal cells express the cell surface marker CD133 and are restricted to the alpha(2)beta(1)(hi) population, previously shown to be a marker of stem cells in prostate epithelia (Collins, A. T., Habib, F. K., Maitland, N. J. and Neal, D. E. (2001). J. Cell Sci. 114, 3865-3872). alpha(2)beta(1)(hi)/CD133(+) cells exhibit two important attributes of epithelial stem cells: they possess a high in vitro proliferative potential and can reconstitute prostatic-like acini in immunocompromised male nude mice. |
| Document Type: Article |
| Language: English |
| Reprint Address: Collins, AT (reprint author), Univ Newcastle Upon Tyne, Sch Med, Prostate Res Grp, Framlington Pl, Newcastle Upon Tyne NE2 4HH, Tyne & Wear England |
Addresses:
1. Univ Newcastle Upon Tyne, Sch Med, Prostate Res Grp, Newcastle Upon Tyne NE2 4HH, Tyne & Wear England
2. Univ York, Dept Biol, YCR Canc Res Unit, York YO10 5DD, N Yorkshire England
3. Univ Cambridge, Addenbrookes Hosp, Dept Oncol, Cambridge CB2 2QQ, England |
| Publisher: COMPANY OF BIOLOGISTS LTD, BIDDER BUILDING CAMBRIDGE COMMERCIAL PARK COWLEY RD, CAMBRIDGE CB4 4DL, CAMBS, ENGLAND |
| Subject Category: Cell Biology |
| IDS Number: 849FG |
| ISSN: 0021-9533 |
| DOI: 10.1242/jcs.01222 |
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