| | |  | | | | Record from Web of Science® | | | | | | |
| Regulation of histone deacetylase activities |
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| Author(s): Sengupta N, Seto E |
| Source: JOURNAL OF CELLULAR BIOCHEMISTRY Volume: 93 Issue: 1 Pages: 57-67 Published: SEP 1 2004 |
| Times Cited: 96 References: 103 |
| Abstract: Histone deacetylases (HDACs) are enzymes that catalyze the removal of acetyl groups from lysine residues in both histone and non-histone proteins. They play a key role in the regulation of gene transcription and many other biological processes involving chromatin. Significantly, recent studies suggest that HDACs are critically involved in cell-cycle regulation, cell proliferation, differentiation, and in the development of human cancer. HDAC inhibitors currently are being exploited as potential anti-cancer agents. As expected for vital regulators of many cellular processes, the activities of HDACs are tightly controlled and precisely regulated by multiple mechanisms. The activities of most if not all HDACs are regulated by protein-protein interactions. In addition, many HDACs are regulated by post-translational modifications as well as by subcellular localization. Less studied, but perhaps equally important, is the regulation of some HDACs by control of expression, availability of cofactors, and by proteolytic processing. A complete understanding of how HDACs are regulated will contribute not only to our overall knowledge of chromatin structure and gene control, but will offer tremendous insight into approaches for developing therapeutic HDAC inhibitors with improved specificity. (C) 2004 Wiley-Liss, Inc. |
| Document Type: Review |
| Language: English |
| Reprint Address: Seto, E (reprint author), H Lee Moffitt Canc Ctr & Res Inst, 12902 Magnolia Dr, Tampa, FL 33612 USA |
Addresses:
1. H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA |
| Publisher: WILEY-LISS, DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: 851CU |
| ISSN: 0730-2312 |
| DOI: 10.1002/jcb.20179 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |