| | |  | | | | Record from Web of Science® | | | | | | |
| Extensive sex-specific nonadditivity of gene expression in Drosophila melanogaster |
|
|
| Author(s): Gibson G, Riley-Berger R, Harshman L, Kopp A, Vacha S, Nuzhdin S, Wayne M |
| Source: GENETICS Volume: 167 Issue: 4 Pages: 1791-1799 Published: AUG 2004 |
| Times Cited: 81 References: 33 |
| Abstract: Assessment of the degree to which gene expression is additive and heritable has important implications for understanding the maintenance of variation, adaptation, phenotypic divergence, and the mapping of genotype onto phenotype. We used whole-genome transcript profiling using Agilent long-oligonucleotide microarrays representing 12,017 genes to demonstrate that gene transcription is pervasively nonadditive in Drosophila melanogaster. Comparison of adults of two isogenic lines and their reciprocal F-1 hybrids revealed 5820 genes as significantly different between at least two of the four genotypes in either males or females or across both sexes. Strikingly, while 25% of all genes differ between the two parents, 33% differ between both F-1's and the parents, averaged across sexes. However, only 5% of genes show overdominance, suggesting that heterosis for expression is rare. |
| Document Type: Article |
| Language: English |
| Reprint Address: Wayne, M (reprint author), Univ Florida, Dept Zool, Box 118525, Gainesville, FL 32611 USA |
Addresses:
1. Univ Florida, Dept Zool, Gainesville, FL 32611 USA
2. N Carolina State Univ, Dept Genet, Raleigh, NC 27695 USA
3. Univ Nebraska, Sch Biol Sci, Lincoln, NE 68588 USA
4. Univ Calif Davis, Ctr Genet & Dev, Davis, CA 95616 USA
5. Agilent Technol, Germantown, MD 20874 USA
6. Univ Calif Davis, Dept Ecol & Evolut, Davis, CA 95616 USA |
| Publisher: GENETICS, 428 EAST PRESTON ST, BALTIMORE, MD 21202 USA |
| Subject Category: Genetics & Heredity |
| IDS Number: 851XR |
| ISSN: 0016-6731 |
| DOI: 10.1534/genetics.104.026583 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |