| | |  | | | | Record from Web of Science® | | | | | | |
| Genetic programs regulating HSC specification, maintenance and expansion |
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| Author(s): Lessard J, Faubert A, Sauvageau G |
| Source: ONCOGENE Volume: 23 Issue: 43 Pages: 7199-7209 Published: SEP 20 2004 |
| Times Cited: 20 References: 127 |
| Abstract: All mature blood cells originate from a small population of self-renewing pluripotent hematopoietic stem cells (HSCs). The capacity to self-renew characterizes all stem cells, whether normal or neoplastic. Interestingly, recent studies suggest that self-renewal is essential for tumor cell maintenance, implicating that this process has therapeutic relevance. Unfortunately, the molecular bases for self-renewal of vertebrate cells remain poorly defined. This article will focus on the developmental mechanisms underlying fetal and adult HSC homeostasis. Specifically, distinctions between genetic programs regulating HSC specification (identity), self-renewal (in both fetal and adult) and differentiation/commitment will be discussed with a special emphasis on transcriptional and chromatin regulators. |
| Document Type: Review |
| Language: English |
| Reprint Address: Sauvageau, G (reprint author), Univ Montreal, Lab Mol Genet Hematopoiet Stem Cells, Res Inst Immunol & Canc IRIC, CP 6128,Succ Ctr Ville, Montreal, PQ H3C 3J7 Canada |
Addresses:
1. Univ Montreal, Lab Mol Genet Hematopoiet Stem Cells, Res Inst Immunol & Canc IRIC, Montreal, PQ H3C 3J7 Canada
2. Stanford Univ, Dept Dev Biol, Stanford, CA 94305 USA
3. Dept Med, Montreal, PQ H3C 3J7 Canada
4. Maisonneuve Rosemont Hosp, Dept Hematol, Montreal, PQ H1T 2M2 Canada
5. McGill Univ, Dept Expt Med, Montreal, PQ Canada |
| Publisher: NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND |
| Subject Category: Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics & Heredity |
| IDS Number: 855TZ |
| ISSN: 0950-9232 |
| DOI: 10.1038/sj.onc.1207940 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |