| | |  | | | | Record from Web of Science® | | | | | | |
| No genetic association between polymorphisms in the AMPA receptor subunit GluR4 gene (GRIA4) and schizophrenia in the Chinese population |
|
|
| Author(s): Guo SZ, Shi YY, Zhao XZ, Duan SW, Zhou J, Meng JW, Yang YF, Gu NF, Feng GY, Liu HJ, Zhu SM, He L |
| Source: NEUROSCIENCE LETTERS Volume: 369 Issue: 2 Pages: 168-172 Published: OCT 14 2004 |
| Times Cited: 6 References: 25 |
| Abstract: The glutamatergic dysfunction hypothesis of schizophrenia suggests genes involved in glutamatergic transmission as candidates for schizophrenia-susceptibility genes. It has recently been reported that some haplotypes in the AMPA receptor subunit GluR4 Gene (GRIA4), which is located on chromosome 11q22, are positively associated with schizophrenia in the Japanese population. In order to assess the role of GRIA4 in schizophrenia, we examined three reported positive SNPs (single nucleotide polymorphisms): rs609239, rs641574 and rs659840 at the GRIA4 locus in schizophrenic cases (n = 372) and controls (n = 392) of the Chinese population. Although we had observed similar allele and genotype frequencies compared with that in the Japanese population, no evidence was found for association with the disease in the analysis of either single nucleotide polymorphisms (all P-values > 0.300) or haplotype relative risk (all P-values > 0.088). Our results suggest that the three SNPs of GRIA4 are unlikely to play a major role in the susceptibility to schizophrenia in the Chinese population. (C) 2004 Elsevier Ireland Ltd. All rights reserved. |
| Document Type: Article |
| Language: English |
| Reprint Address: He, L (reprint author), Shanghai Jiao Tong Univ, Bio X Life Sci Res Ctr, 1954 Huashan Rd, Shanghai 200030, Peoples R China |
Addresses:
1. Shanghai Jiao Tong Univ, Bio X Life Sci Res Ctr, Shanghai 200030, Peoples R China
2. CAS, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai 200031, Peoples R China
3. Shanghai Inst Mental Hlth, Shanghai 200030, Peoples R China
4. Jilin Inst Mental Hlth, Jilin 136000, Peoples R China
5. Chinese Acad Sci, SIBS, NHGG, Inst Nutr Sci, Shanghai 200031, Peoples R China |
| Publisher: ELSEVIER SCI IRELAND LTD, CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND |
| Subject Category: Neurosciences |
| IDS Number: 861SE |
| ISSN: 0304-3940 |
| DOI: 10.1016/j.neulet.2004.07.079 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |