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| An alternative approach to age adjustment of cancer survival rates |
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| Author(s): Brenner H, Arndt V, Gefeller O, Hakulinen T |
| Source: EUROPEAN JOURNAL OF CANCER Volume: 40 Issue: 15 Pages: 2317-2322 Published: OCT 2004 |
| Times Cited: 19 References: 16 |
| Abstract: The measures of cancer prognosis most commonly reported by cancer registries are 5- or 10-year absolute or relative survival rates. Because cancer survival rates often vary by the age of cancer patients, and because the age structure of cancer patients often varies between populations, age adjustment is crucial for comparative analyses of cancer survival rates. However, traditional age adjustment often breaks down for long-term survival rates, particularly for sparse data, and it may provide inconsistent results for relative survival rates, even if age adjustment is made to the study population's own age distribution. In this manuscript, we propose an alternative approach to age adjustment of both absolute and relative survival rates to overcome both the practical and conceptual problems inherent in traditional age adjustment. We outline the computational realisation of this approach, and we give an empirical illustration of its application using data from the nationwide Finnish Cancer Registry. (C) 2004 Elsevier Ltd. All rights reserved. |
| Document Type: Article |
| Language: English |
| Reprint Address: Brenner, H (reprint author), German Ctr Res Ageing, Dept Epidemiol, Bergheimer Str 20, D-69115 Heidelberg, Germany |
Addresses:
1. German Ctr Res Ageing, Dept Epidemiol, D-69115 Heidelberg, Germany
2. Univ Erlangen Nurnberg, Dept Med Informat Biometry & Epidemiol, D-91504 Erlangen, Germany
3. Finnish Canc Registry, FIN-00170 Helsinki, Finland
4. Univ Helsinki, Dept Publ Hlth, FIN-00170 Helsinki, Finland |
| Publisher: PERGAMON-ELSEVIER SCIENCE LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND |
| Subject Category: Oncology |
| IDS Number: 865SW |
| ISSN: 0959-8049 |
| DOI: 10.1016/j.ejca.2004.07.007 |
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