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| Biological robustness |
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| Author(s): Kitano H |
| Source: NATURE REVIEWS GENETICS Volume: 5 Issue: 11 Pages: 826-837 Published: NOV 2004 |
| Times Cited: 269 References: 133 |
| Abstract: Robustness is a ubiquitously observed property of biological systems. It is considered to be a fundamental feature of complex evolvable systems. It is attained by several underlying principles that are universal to both biological organisms and sophisticated engineering systems. Robustness facilitates evolvability and robust traits are often selected by evolution. Such a mutually beneficial process is made possible by specific architectural features observed in robust systems. But there are trade-offs between robustness, fragility, performance and resource demands, which explain system behaviour, including the patterns of failure. Insights into inherent properties of robust systems will provide us with a better understanding of complex diseases and a guiding principle for therapy design. |
| Document Type: Review |
| Language: English |
| Reprint Address: Kitano, H (reprint author), Sony Comp Sci Labs Inc, Shinagawa Ku, 3-14-13 Higashi Gotanda, Tokyo 1410022, Japan |
Addresses:
1. Sony Comp Sci Labs Inc, Shinagawa Ku, Tokyo 1410022, Japan
2. Syst Biol Inst, Tokyo 1500001, Japan |
| Publisher: NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND |
| Subject Category: Genetics & Heredity |
| IDS Number: 867HG |
| ISSN: 1471-0056 |
| DOI: 10.1038/nrg1471 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |