| | |  | | | | Record from Web of Science® | | | | | | |
| T-lymphocyte death during shutdown of an immune response |
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| Author(s): Strasser A, Pellegrini M |
| Source: TRENDS IN IMMUNOLOGY Volume: 25 Issue: 11 Pages: 610-615 Published: NOV 2004 |
| Times Cited: 76 References: 60 |
| Abstract: The immune system serves to protect organisms from infectious pathogens. During infection, lymphocytes and cells of the innate immune system, expressing receptors that recognize foreign antigens, proliferate and differentiate to develop effector functions that help to kill the pathogens. Effector functions, such as cellular or antibody mediated cytotoxicity, and inflammatory cytokines can be harmful to the host. To limit damage to healthy tissue, mechanisms have evolved to shut down immune responses, including cell inactivation and cell death. Here we discuss recent studies demonstrating that the death of antigen-activated T lymphocytes during termination of an immune response is initiated by the BH3-only Bcl-2 family member Bim and also requires its multi-BH domain pro-apoptotic relatives Bax and Bak. |
| Document Type: Review |
| Language: English |
| Reprint Address: Strasser, A (reprint author), Walter & Eliza Hall Inst Med Res, Mol Genet Canc Div, 1G Royal Parade, Parkville, Vic 3050 Australia |
Addresses:
1. Walter & Eliza Hall Inst Med Res, Mol Genet Canc Div, Parkville, Vic 3050 Australia
2. Ontario Canc Inst, AMDI, Toronto, ON M5G 2C1 Canada |
| Publisher: ELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND |
| Subject Category: Immunology |
| IDS Number: 869GA |
| ISSN: 1471-4906 |
| DOI: 10.1016/j.it.2004.08.012 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |