| | |  | | | | Record from Web of Science® | | | | | | |
| Retrovirus budding |
|
|
| Author(s): Morita E, Sundquist WI |
| Source: ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY Volume: 20 Pages: 395-425 Published: 2004 |
| Times Cited: 285 References: 162 |
| Abstract: Human immunodeficiency virus (HIV) and other retroviruses acquire their envelopes and spread infection by budding through the limiting membranes of producer cells. To facilitate budding, retroviruses usurp a cellular pathway that is normally used to create vesicles that bud into late endosomal compartments called multivesicular bodies (MVB). Research on yeast and human MVB biogenesis has led to the identification of similar to 25 human proteins that are required for vesicle formation and for HIV-1 budding, and has produced a working model for sequential recruitment of these proteins during MVB vesicle formation. Retroviruses can redirect this machinery to the plasma membrane and leave the cell in a single step or, alternatively, can bud directly into MVB compartments and then exit cells via the exosome pathway. Remarkably, virus release from both the plasma membrane and MVB compartments can occur directionally into specialized sites of cell-to-cell contact called virological synapses. Thus retroviruses have evolved elaborate mechanisms for escaping the cell and maximizing their chances of infecting a new host. |
| Document Type: Review |
| Language: English |
| Reprint Address: Morita, E (reprint author), Univ Utah, Dept Biochem, Salt Lake City, UT 84132 USA |
Addresses:
1. Univ Utah, Dept Biochem, Salt Lake City, UT 84132 USA |
| Publisher: ANNUAL REVIEWS, 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0139 USA |
| Subject Category: Cell Biology; Developmental Biology |
| IDS Number: 873YQ |
| ISSN: 1081-0706 |
| DOI: 10.1146/annurev.cellbio.20.010403.102350 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |