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| The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses |
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| Author(s): Li Z, Okamoto K, Hayashi Y, Sheng M |
| Source: CELL Volume: 119 Issue: 6 Pages: 873-887 Published: DEC 17 2004 |
| Times Cited: 241 References: 38 |
| Abstract: The proper intracellular distribution of mitochondria is assumed to be critical for normal physiology of neuronal cells, but direct evidence for this idea is lacking. Extension or movement of mitochondria into dendritic protrusions correlates with the development and morphological plasticity of spines. Molecular manipulations of dynamin-like GTPases Drp1 and OPA1 that reduce dendritic mitochondria content lead to loss of synapses and dendritic spines, whereas increasing dendritic mitochondrial content or mitochondrial activity enhances the number and plasticity of spines and synapses. Thus, the dendritic distribution of mitochondria is essential and limiting for the support of synapses. Reciprocally, synaptic activity modulates the motility and fusion/fission balance of mitochondria and controls mitochondrial distribution in dendrites. |
| Document Type: Article |
| Language: English |
| Reprint Address: Sheng, M (reprint author), MIT, Picower Ctr Learning & Memory, RIKEN, Ctr Res Neurosci, 77 Massachusetts Ave, Cambridge, MA 02139 USA |
Addresses:
1. MIT, Picower Ctr Learning & Memory, RIKEN, Ctr Res Neurosci, Cambridge, MA 02139 USA
2. MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA |
| Publisher: CELL PRESS, 1100 MASSACHUSETTS AVE, CAMBRIDGE, MA 02138 USA |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: 881ZD |
| ISSN: 0092-8674 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |